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NMR structure of the WIF domain of the human Wnt-inhibitory factor-1

Liepinsh, Edvards; Banyai, Laszlo; Patthy, Laszlo; Otting, Gottfried


The human Wnt-binding protein Wnt-inhibitory factor-1 (WIF-1) comprises an N-terminal WIF module followed by five EGF-like repeats. Here we report the three-dimensional structure of the WIF domain of WIF-1 determined by NMR spectroscopy. The fold consists of an eight-stranded β-sandwich reminiscent of the immunoglobulin fold. Residual detergent (Brij-35) used in the refolding protocol was found to bind tightly to the WIF domain. The binding site was identified by intermolecular nuclear...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2006.01.047


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