Ekblad, Maria; Bergstrom, Tomas; Banwell, Martin; Bonnet, Muriel; Renner, Jens; Ferro, Vito; Trybala, Edward
By screening a library of sulphated compounds of low molecular weight, we have found that several cyclitol derivatives, each modified with two sulphate groups in addition to pyrrole and various aromatic moieties, inhibited infectivity of herpes simplex virus (HSV) at concentrations approximately 100 times lower than those toxic for cultured cells. These disulphated cyclitols interfered with HSV-1 attachment to cells, and efficiently reduced the cell-to-cell spread of the virus. This effect is...[Show more]
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