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CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood

Warren, Hilary; Rana, Purna; Hewitt, Kimberley; Rieger, Duncan; Dahlstrom, Jane; Kent, Alison

Description

We report that natural killer receptors (NKR) for major histocompatibility complex (MHC) class I molecules (MHC-NKR), the inhibitory killer immunoglobulin-like receptors (KIR), and the CD94/NKG2A receptor are present on a small proportion of CD8 T cells in cord blood. On average, 1.67% of CD8 T cells in cord blood express KIR, and 0.74% expresses NKG2A, approximately five-fold less than in adult blood. CD8 T cells expressing MHC-NKR were present at similar levels in cord blood from preterm and...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85197
Source: Journal of Leukocyte Biology
DOI: 10.1189/jlb.0905536

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