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Biological, antigenic and phylogenetic characterization of the flavivirus Alfuy

May, Fiona J; Lobigs, Mario; Lee, Eva; Gendle, Debra J; Mackenzie, John S; Broom, Annette; Conlan, James V; Hall, Roy A


Alfuy virus (ALFV) is classified as a subtype of the flavivirus Murray Valley encephalitis virus (MVEV); however, despite preliminary reports of antigenic and ecological similarities with MVEV, ALFV has not been associated with human disease. Here, it was shown that ALFV is at least 104-fold less neuroinvasive than MVEV after peripheral inoculation of 3-week-old Swiss outbred mice, but ALFV demonstrates similar neurovirulence. In addition, it was shown that ALFV is partially attenuated in mice...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.81252-0


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