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Obligatory requirement for antibody in recovery from a primary poxvirus infection

Chaudhri, Geeta; Panchanathan, Vijay; Bluethmann, Horst; Karupiah, Gunasegaran

Description

To understand the correlates of protective immunity against primary variola virus infection in humans, we have used the well-characterized mousepox model. This is an excellent surrogate small-animal model for smallpox in which the disease is caused by infection with the closely related orthopoxvirus, ectromelia virus. Similarities between the two infections include virus replication and transmission, aspects of pathology, and development of pock lesions. Previous studies using ectromelia virus...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85193
Source: Journal of Virology
DOI: 10.1128/JVI.00116-06

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