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Sodium-dependent uptake of inorganic phosphate by the intracelluar malaria parasite

Saliba, Kevin; Martin, Rowena; Broer, Angelika; Henry, Roselani; McCarthy, Siobhan; Downie, Megan; Allen, Richard; Mullin, Kylie; McFadden, Geoffrey I; Broer, Stefan; Kirk, Kiaran

Description

As the malaria parasite, Plasmodium falciparum, grows within its host erythrocyte it induces an increase in the permeability of the erythrocyte membrane to a range of low-molecular-mass solutes, including Na+ and K+ (ref. 1). This results in a progressive increase in the concentration of Na+ in the erythrocyte cytosol. The parasite cytosol has a relatively low Na+ concentration and there is therefore a large inward Na+ gradient across the parasite plasma membrane. Here we show that the parasite...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85184
Source: Nature
DOI: 10.1038/nature05149

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