Sodium-dependent uptake of inorganic phosphate by the intracelluar malaria parasite
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Saliba, Kevin; Martin, Rowena; Broer, Angelika; Henry, Roselani; McCarthy, Siobhan; Downie, Megan; Allen, Richard; Mullin, Kylie; McFadden, Geoffrey I; Broer, Stefan; Kirk, Kiaran
Description
As the malaria parasite, Plasmodium falciparum, grows within its host erythrocyte it induces an increase in the permeability of the erythrocyte membrane to a range of low-molecular-mass solutes, including Na+ and K+ (ref. 1). This results in a progressive increase in the concentration of Na+ in the erythrocyte cytosol. The parasite cytosol has a relatively low Na+ concentration and there is therefore a large inward Na+ gradient across the parasite plasma membrane. Here we show that the parasite...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/85184 |
Source: | Nature |
DOI: | 10.1038/nature05149 |
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