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A single amino acid substitution in the West Nile Virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice

Liu, Weihua; Wang, Xiang; Clark, David C; Lobigs, Mario; Hall, Roy A; Khromykh, Alexander A

Description

Alpha/beta interferons (IFN-α/β) are key mediators of the innate immune response against viral infection. The ability of viruses to circumvent IFN-α/β responses plays a crucial role in determining the outcome of infection. In a previous study using su

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85177
Source: Journal of Virology
DOI: 10.1128/JVI.80.5.2396-2404.2006

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