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Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane

Baumeister, Stefan; Winterberg, Markus; Duranton, Christophe; Huber, Stephan J; Lang, Florian; Kirk, Kiaran; Lingelbach, Klaus


The intraerythrocytic developmental stages of the malaria parasite Plasmodium falciparum are responsible for the clinical symptoms associated with malaria tropica. The non-infected human erythrocyte is a terminally differentiated cell that is unable to synthesize proteins and lipids de novo, and it is incapable of importing a number of solutes that are essential for parasite proliferation. Approximately 12-15 h after invasion the parasitized cell undergoes a marked increase in its permeability...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/j.1365-2958.2006.05112.x


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