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Two Families of Rep-Like Genes That Probably Originated by Interspecies Recombination Are Represented in Viral, Plasmid, Bacterial, and Parasitic Protozoan Genomes

Gibbs, Mark; Smeianov, Vladimir; Steele, James; Upcroft, Peter; Efimov, Boris

Description

Two families of genes related to, and including, rolling circle replication initiator protein (Rep) genes were defined by sequence similarity and by evidence of intergene family recombination. The Rep genes of circoviruses were the best characterized members of the "RecRep1 family." Other members of the RecRep1 family were Rep-like genes found in the genomes of the Canarypox virus, Entamoeba histolytica, and Giardia duodenalis and in a plasmid, p4M, from the Gram-positive bacterium,...[Show more]

dc.contributor.authorGibbs, Mark
dc.contributor.authorSmeianov, Vladimir
dc.contributor.authorSteele, James
dc.contributor.authorUpcroft, Peter
dc.contributor.authorEfimov, Boris
dc.date.accessioned2015-12-13T23:03:58Z
dc.identifier.issn0737-4038
dc.identifier.urihttp://hdl.handle.net/1885/85161
dc.description.abstractTwo families of genes related to, and including, rolling circle replication initiator protein (Rep) genes were defined by sequence similarity and by evidence of intergene family recombination. The Rep genes of circoviruses were the best characterized members of the "RecRep1 family." Other members of the RecRep1 family were Rep-like genes found in the genomes of the Canarypox virus, Entamoeba histolytica, and Giardia duodenalis and in a plasmid, p4M, from the Gram-positive bacterium, Bifidobacterium pseudocatenulatum. The "RecRep2 family" comprised some previously identified Rep-like genes from plasmids of phytoplasmas and similar Rep-like genes from the genomes of Lactobacillus acidophilus, Lactococcus lactis, and Phytoplasma asteris. Both RecRep1 and RecRep2 proteins have a nucleotide-binding domain significantly similar to the helicases (2C proteins) of picorna-like viruses. On the N-terminal side of the nucleotide binding domain, RecRep1 proteins have a domain significantly similar to one found in nanovirus Reps, whereas RecRep2 proteins have a domain significantly similar to one in the Reps of pLS1 plasmids. We speculate that RecRep genes have been transferred from viruses or plasmids to parasitic protozoan and bacterial genomes and that Rep proteins were themselves involved in the original recombination events that generated the ancestral RecRep genes.
dc.publisherSociety for Molecular Biology Evolution
dc.sourceMolecular Biology and Evolution
dc.subjectKeywords: helicase; replication initiator protein; unclassified drug; amino terminal sequence; article; bacterial genome; Bifidobacterium; Canarypox virus; Circoviridae; Entamoeba histolytica; evidence based medicine; family; gene; gene identification; gene sequenc Circovirus; Gene family; Interspecies recombination; Parasitic protozoan; pLS1 plasmid; RecRep1
dc.titleTwo Families of Rep-Like Genes That Probably Originated by Interspecies Recombination Are Represented in Viral, Plasmid, Bacterial, and Parasitic Protozoan Genomes
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume23
dc.date.issued2006
local.identifier.absfor060506 - Virology
local.identifier.ariespublicationMigratedxPub13406
local.type.statusPublished Version
local.contributor.affiliationGibbs, Mark, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSmeianov, Vladimir, University of Wisconsin
local.contributor.affiliationSteele, James, University of Wisconsin
local.contributor.affiliationUpcroft, Peter, Queensland Institute of Medical Research
local.contributor.affiliationEfimov, Boris, Russian State Medical University
local.description.embargo2037-12-31
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage1097
local.bibliographicCitation.lastpage1100
local.identifier.doi10.1093/molbev/msj122
dc.date.updated2015-12-12T07:52:40Z
local.identifier.scopusID2-s2.0-33646872444
CollectionsANU Research Publications

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