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The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

Pardo, Julian; Urban, Christian; Galvez, Eva; Ekert, Paul; Muller, Uwe; Kwon-Chung, June Kyung; Lobigs, Mario; Mullbacher, Arno; Wallich, Reinhard; Barner, Christopher; Simon, Markus M

Description

Aspergillus fumigatus infections cause high levels of morbidity and mortality in immunocompromised patients. Gliotoxin (GT), a secondary metabolite, is cytotoxic for mammalian cells, but the molecular basis and biological relevance of this toxicity remain speculative. We show that GT induces apoptotic cell death by activating the proapoptotic Bcl-2 family member Bak, but not Bax, to elicit the generation of reactive oxygen species, the mitochondrial release of apoptogenic factors, and caspase-3...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85150
Source: Journal of Cell Biology
DOI: 10.1083/jcb.200604044

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