Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase
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Shield, Alison; Murray, Tracy; Board, Philip
Description
Mutations in the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene have been linked with Charcot-Marie-Tooth (CMT) disease. This protein, and its paralogue GDAP1L1, appear to be structurally related to the cytosolic glutathione S-transferases (GST) including an N-terminal thioredoxin fold domain with conserved active site residues. The specific function, of GDAP1 remains unknown. To further characterise their structure and function we purified recombinant human GDAP1 and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/85136 |
Source: | Biochemical and Biophysical Research Communications |
DOI: | 10.1016/j.bbrc.2006.06.189 |
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