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Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase

Shield, Alison; Murray, Tracy; Board, Philip


Mutations in the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene have been linked with Charcot-Marie-Tooth (CMT) disease. This protein, and its paralogue GDAP1L1, appear to be structurally related to the cytosolic glutathione S-transferases (GST) including an N-terminal thioredoxin fold domain with conserved active site residues. The specific function, of GDAP1 remains unknown. To further characterise their structure and function we purified recombinant human GDAP1 and...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2006.06.189


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