ENU-mutagenesis: insight into immune function and pathology
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Cook, Matthew; Garcia De Vinuesa, Maria Carola; Goodnow, Christopher
Description
In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations.
dc.contributor.author | Cook, Matthew | |
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dc.contributor.author | Garcia De Vinuesa, Maria Carola | |
dc.contributor.author | Goodnow, Christopher | |
dc.date.accessioned | 2015-12-13T23:03:55Z | |
dc.identifier.issn | 0952-7915 | |
dc.identifier.uri | http://hdl.handle.net/1885/85135 | |
dc.description.abstract | In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations. | |
dc.publisher | Elsevier | |
dc.source | Current Opinion in Immunology | |
dc.subject | Keywords: autoantibody; nitrosourea; allele; allergy; antibody producing cell; autoimmunity; complex formation; gene mutation; gene number; genetic screening; homozygosity; host resistance; human; hypersensitivity; immune function test; immune response; inheritance | |
dc.title | ENU-mutagenesis: insight into immune function and pathology | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 18 | |
dc.date.issued | 2006 | |
local.identifier.absfor | 110703 - Autoimmunity | |
local.identifier.ariespublication | MigratedxPub13374 | |
local.type.status | Published Version | |
local.contributor.affiliation | Cook, Matthew, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Garcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Goodnow, Christopher, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 627 | |
local.bibliographicCitation.lastpage | 633 | |
local.identifier.doi | 10.1016/j.coi.2006.07.011 | |
dc.date.updated | 2015-12-12T07:52:15Z | |
local.identifier.scopusID | 2-s2.0-33748325753 | |
Collections | ANU Research Publications |
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