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ENU-mutagenesis: insight into immune function and pathology

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Cook, Matthew; Garcia De Vinuesa, Maria Carola; Goodnow, Christopher

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In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations.

dc.contributor.authorCook, Matthew
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T23:03:55Z
dc.identifier.issn0952-7915
dc.identifier.urihttp://hdl.handle.net/1885/85135
dc.description.abstractIn random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations.
dc.publisherElsevier
dc.sourceCurrent Opinion in Immunology
dc.subjectKeywords: autoantibody; nitrosourea; allele; allergy; antibody producing cell; autoimmunity; complex formation; gene mutation; gene number; genetic screening; homozygosity; host resistance; human; hypersensitivity; immune function test; immune response; inheritance
dc.titleENU-mutagenesis: insight into immune function and pathology
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume18
dc.date.issued2006
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationMigratedxPub13374
local.type.statusPublished Version
local.contributor.affiliationCook, Matthew, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage627
local.bibliographicCitation.lastpage633
local.identifier.doi10.1016/j.coi.2006.07.011
dc.date.updated2015-12-12T07:52:15Z
local.identifier.scopusID2-s2.0-33748325753
CollectionsANU Research Publications

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