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ENU-mutagenesis: insight into immune function and pathology

Cook, Matthew; Garcia De Vinuesa, Maria Carola; Goodnow, Christopher

Description

In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85135
Source: Current Opinion in Immunology
DOI: 10.1016/j.coi.2006.07.011

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