ENU-mutagenesis: insight into immune function and pathology
In random chemical mutagenesis, gene discovery is driven by phenotypes rather than by hypotheses. A standard dose of N-ethyl-N-nitrosourea results in ∼30 coding mutations in male G1 mice, of which ∼4 can be propagated to homozygosity in 3 generations.
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|Source:||Current Opinion in Immunology|
|01_Cook_ENU-mutagenesis:_insight_into_2006.pdf||147.99 kB||Adobe PDF||Request a copy|
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