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Hypothesis: A biological role for germline transcription in the mechanism of V(D)J recombination - implications for initiation of allelic exclusion

Franklin, Andrew


The sequences that encode the antigen-binding sites of IgH and IgL chains - variable (V), diversity (D, H chain loci only) and joining (J) sequences - are configured as separate DNA segments at the germline level. Expression of an Ig molecule requires V(D)J assembly. Productive V(D)J recombination is monoallelic. How rearrangement is initiated differentially at maternal and paternal alleles is unclear. The products of recombination activating gene (RAG)1 and RAG2 mediate rearrangement by...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1111/j.1440-1711.2006.01437.x


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