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Characterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes

Prichard, Zoe; Easteal, Simon

Description

Simple sequence repeats (SSRs) have traditionally been used as markers in gene mapping studies and typing for forensic purposes. Recently there has been some speculation that this type of genetic variation also plays a more direct role in influencing gene expression and hence complex phenotypic outcomes such as human behavior. For this reason it is interesting to investigate SSRs linked to candidate genes for various complex phenotypes. An economical multiplex PCR-based assay was designed to...[Show more]

dc.contributor.authorPrichard, Zoe
dc.contributor.authorEasteal, Simon
dc.date.accessioned2015-12-13T23:02:40Z
dc.date.available2015-12-13T23:02:40Z
dc.identifier.issn1059-7794
dc.identifier.urihttp://hdl.handle.net/1885/84997
dc.description.abstractSimple sequence repeats (SSRs) have traditionally been used as markers in gene mapping studies and typing for forensic purposes. Recently there has been some speculation that this type of genetic variation also plays a more direct role in influencing gene expression and hence complex phenotypic outcomes such as human behavior. For this reason it is interesting to investigate SSRs linked to candidate genes for various complex phenotypes. An economical multiplex PCR-based assay was designed to simultaneously genotype individuals at 15 loci across 10 candidate genes for human behavioural phenotypes, including seven loci previously unreported in Caucasians (five unreported in any population). All loci were tested for Hardy-Weinberg equilibrium and for two-locus Linkage Disequilibrium. Ewens-Watterson neutrality testing indicated possible selection at a previously unreported DRD2 locus. 2005 Wiley-Liss, Inc.
dc.publisherWiley-Liss Inc
dc.sourceHuman Mutation
dc.subjectKeywords: adult; allele; article; behavior genetics; exon; gene frequency; genetic variability; genetics; homozygote; human; mutation; nucleotide repeat; phenotype; Adult; Alleles; Exons; Gene Frequency; Genetics, Behavioral; Homozygote; Humans; Mutation; Phenotype
dc.titleCharacterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume27
dc.date.issued2006
local.identifier.absfor060499 - Genetics not elsewhere classified
local.identifier.ariespublicationMigratedxPub13201
local.type.statusPublished Version
local.contributor.affiliationPrichard, Zoe, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationEasteal, Simon, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage120
dc.date.updated2015-12-12T07:48:46Z
local.identifier.scopusID2-s2.0-34548351777
CollectionsANU Research Publications

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