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Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin

Bulynko, Yaroslava; Hsing, Lianne; Mason, Robert; Tremethick, David; Grigoriev, Sergei A


Posttranslational histone modifications and histone variants form a unique epigenetic landscape on mammalian chromosomes where the principal epigenetic heterochromatin markers, trimethylated histone H3(K9) and the histone H2A.Z, are inversely localized in relation to each other. Trimethylated H3(K9) marks pericentromeric constitutive heterochromatin and the male Y chromosome, while H2A.Z is dramatically reduced at these chromosomal locations. Inactivation of a lysosomal and nuclear protease,...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Molecular and Cellular Biology
DOI: 10.1128/MCB.00135-06


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