Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin
Posttranslational histone modifications and histone variants form a unique epigenetic landscape on mammalian chromosomes where the principal epigenetic heterochromatin markers, trimethylated histone H3(K9) and the histone H2A.Z, are inversely localized in relation to each other. Trimethylated H3(K9) marks pericentromeric constitutive heterochromatin and the male Y chromosome, while H2A.Z is dramatically reduced at these chromosomal locations. Inactivation of a lysosomal and nuclear protease,...[Show more]
|Collections||ANU Research Publications|
|Source:||Molecular and Cellular Biology|
|01_Bulynko_Cathepsin_L_stabilizes_the_2006.pdf||1.28 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.