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Synthesis of NTA 3 -DTDA - A Chelator-Lipid that Promotes Stable Binding of His-Tagged Proteins to Membranes

Altin, Joseph; Banwell, Martin; Coghlan, Phillip; Easton, Christopher; Nairn, Michael; Offermann, Daniel


A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH06112


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