Dendritic synapse location and neocortical spike-timing-dependent plasticity
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Froemke, Robert C.; Letzkus, Johannes; Kampa, Bjoern; Hang, Giao B.; Stuart, Gregory J
Description
While it has been appreciated for decades that synapse location in the dendritic tree has a powerful influence on signal processing in neurons, the role of dendritic synapse location on the induction of long-term synaptic plasticity has only recently been explored. Here, we review recent work revealing how learning rules for spike-timing-dependent plasticity (STDP) in cortical neurons vary with the spatial location of synaptic input. A common principle appears to be that proximal synapses show...[Show more]
dc.contributor.author | Froemke, Robert C. | |
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dc.contributor.author | Letzkus, Johannes | |
dc.contributor.author | Kampa, Bjoern | |
dc.contributor.author | Hang, Giao B. | |
dc.contributor.author | Stuart, Gregory J | |
dc.date.accessioned | 2015-12-13T23:02:32Z | |
dc.identifier.issn | 1663-3563 | |
dc.identifier.uri | http://hdl.handle.net/1885/84933 | |
dc.description.abstract | While it has been appreciated for decades that synapse location in the dendritic tree has a powerful influence on signal processing in neurons, the role of dendritic synapse location on the induction of long-term synaptic plasticity has only recently been explored. Here, we review recent work revealing how learning rules for spike-timing-dependent plasticity (STDP) in cortical neurons vary with the spatial location of synaptic input. A common principle appears to be that proximal synapses show conventional STDP, whereas distal inputs undergo plasticity according to novel learning rules. One crucial factor determining location-dependent STDP is the backpropagating action potential, which tends to decrease in amplitude and increase in width as it propagates into the dendritic tree of cortical neurons. We discuss additional locationdependent mechanisms as well as the functional implications of heterogeneous learning rules at different dendritic locations for the organization of synaptic inputs. | |
dc.publisher | Frontiers Media | |
dc.source | Frontiers in Synaptic Neuroscience | |
dc.subject | Keywords: 4 aminobutyric acid receptor; brain derived neurotrophic factor; n methyl dextro aspartic acid receptor; action potential; calcium signaling; dendrite; information processing; learning; long term potentiation; memory; neocortex; nerve cell plasticity; neu Cortex; Dendrites; LTD; LTP; NMDA receptors; Spikes; STDP; Synaptic plasticity | |
dc.title | Dendritic synapse location and neocortical spike-timing-dependent plasticity | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 2 | |
dc.date.issued | 2010 | |
local.identifier.absfor | 110902 - Cellular Nervous System | |
local.identifier.ariespublication | f5625xPUB13152 | |
local.type.status | Published Version | |
local.contributor.affiliation | Froemke, Robert C., New York University School of Medicine, | |
local.contributor.affiliation | Letzkus, Johannes, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Kampa, Bjoern, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Hang, Giao B., University of California | |
local.contributor.affiliation | Stuart, Gregory J, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | JUL | |
local.identifier.doi | 10.3389/fnsyn.2010.00029 | |
dc.date.updated | 2016-02-24T08:44:51Z | |
local.identifier.scopusID | 2-s2.0-79957948052 | |
Collections | ANU Research Publications |
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