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Circular micro-proteins and mechanisms of cyclization

Conlan, Brendon; Anderson, Marilyn


Transpeptidation reactions result in the formation of new peptide bonds and this can occur between two separate peptides or within the one peptide. These reactions are catalyzed by enzymes and when the N- and C-terminus of the one peptide are joined it results in the formation of cyclic proteins. Cyclization via head-to-tail linkage of the termini of a peptide chain occurs in only a small percentage of proteins but gives the resultant cyclic proteins exceptional stability. The mechanisms are...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Current Pharmaceutical Design
DOI: 10.2174/138161211798999410


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