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Targeting nucleic acids using dynamic combinatorial chemistry

Durai, Chandramathi R. Sherman; Harding, Margaret


Dynamic combinatorial chemistry (DCC) is a powerful method for the identification of novel ligands for the molecular recognition of receptor molecules. The method relies on self-assembly processes to generate libraries of compounds under reversible conditions, allowing a receptor molecule to select the optimal binding ligand from the mixture. However, while DCC is now an established field of chemistry, there are limited examples of the application of DCC to nucleic acids. The requirement to...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH11023


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