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Leptin: Molecular mechanisms, systemic pro-inflammatory effects, and clinical implications [Leptina: Mecanismos moleculares, efeitos proinflamatorios sistmicos e implicoes clinicas]

Da Paz Filho, Gilberto; Mastronardi, Claudio; Franco, CB; Wang, Kevin; Wong, Ma-Li; Licinio, Julio


Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Arquivos Brasileiros de Endocrinologia e Metabologia
DOI: 10.1590/S0004-27302012000900001


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