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Navigating the fungal polyketide chemical space: From genes to molecules

Chooi, Yit-Heng; Tang, Yi


The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an enormously diverse array of natural products in fungi. These natural products, known as polyketides, exhibit a wide range of biological activities and include clinically important drugs as well as undesirable toxins. The PKSs synthesize these structurally diverse polyketides via a series of decarboxylative condensations of malonyl-CoA extender units and β-keto modifications in a highly programmed manner....[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Organic Chemistry
DOI: 10.1021/jo301592k


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