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Exposure to infant siblings during early life and risk of multiple sclerosis

Ponsonby, Anne-Louise; van der Mei, Ingrid A F; Dwyer, Terence; Blizzard, Leigh; Taylor, Bruce; Kemp, Andrew; Simmons, Rex; Kilpatrick, Trevor


Context: The "hygiene hypothesis" has implicated sibship as a marker of infection load during early life and suggests that exposure or reexposure to infections can influence the developing immune system. Viral infection has also been implicated in the pathogenesis of multiple sclerosis (MS). Objectives: To evaluate whether exposure to infant siblings in early life is associated with the risk of MS, and to explore the possible mechanism for any apparent protective effect, including altered...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: JAMA: The Journal of the American Medical Association
DOI: 10.1001/jama.293.4.463


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