Ponsonby, Anne-Louise; van der Mei, Ingrid A F; Dwyer, Terence; Blizzard, Leigh; Taylor, Bruce; Kemp, Andrew; Simmons, Rex; Kilpatrick, Trevor
Context: The "hygiene hypothesis" has implicated sibship as a marker of infection load during early life and suggests that exposure or reexposure to infections can influence the developing immune system. Viral infection has also been implicated in the pathogenesis of multiple sclerosis (MS). Objectives: To evaluate whether exposure to infant siblings in early life is associated with the risk of MS, and to explore the possible mechanism for any apparent protective effect, including altered...[Show more]
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