Oberdoerffer, Philipp; Kanellopoulou, Chryssa; Heissmeyer, Vigo; Paeper, Corinna; Borowski, Christine; Aifantis, Ianni; Rao, Anjana; Rajewsky, Klaus
RNA interference (RNAi) is a naturally occurring posttranscriptional gene-silencing mechanism that has been adapted as a genetic tool for loss-of-function studies of a variety of organisms. It is more widely applicable than classical gene targeting and allows for the simultaneous inactivation of several homologous genes with a single transgene. Recently, RNAi has been used for conditional and conventional gene inactivation in mice. Unlike gene targeting, RNAi is a dynamic process, and its...[Show more]
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