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Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

Oberdoerffer, Philipp; Kanellopoulou, Chryssa; Heissmeyer, Vigo; Paeper, Corinna; Borowski, Christine; Aifantis, Ianni; Rao, Anjana; Rajewsky, Klaus

Description

RNA interference (RNAi) is a naturally occurring posttranscriptional gene-silencing mechanism that has been adapted as a genetic tool for loss-of-function studies of a variety of organisms. It is more widely applicable than classical gene targeting and allows for the simultaneous inactivation of several homologous genes with a single transgene. Recently, RNAi has been used for conditional and conventional gene inactivation in mice. Unlike gene targeting, RNAi is a dynamic process, and its...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/84802
Source: Molecular and Cellular Biology
DOI: 10.1128/MCB.25.10.3896-3905.2005

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