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Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

Parish, Christopher; Freeman, Craig; Ziolkowski, Andrew; He, Y.Q.; Sutcliffe, Elissa L; Zafar, Anjum; Rao, Sudha; Simeonovic, Charmaine

Description

Heparanase (Hpse) is an endo-β-. d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues. Heparanase activity also releases HS-bound growth factors from the extra

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/84666
Source: Matrix Biology
DOI: 10.1016/j.matbio.2013.02.007

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