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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

Cui, Hao; Freeman, Craig; Jacobson, Glenn A; Small, David H


Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: IUBMB Life
DOI: 10.1002/iub.1118


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