Bacteriophage-encoded glucosyltransferase Gtrll of Shigella flexneri: membrane topology and identification of critical residues

Abstract

The Shigella flexneri serotypes differ in the nature of their O-antigens. The addition of glucosyl or O-acetyl groups to the common backbone repeat units gives rise to the different serotypes. GtrII glucosylates rhamnose III of the O-antigen repeat unit,