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Plasmodium permeomics: membrane transport proteins in the malaria parasite.

Kirk, Kiaran; Martin, Rowena; Broer, Stefan; Howitt, Susan; Saliba, Kevin

Description

Membrane transport proteins are integral membrane proteins that mediate the passage across the membrane bilayer of specific molecules and/or ions. Such proteins serve a diverse range of physiological roles, mediating the uptake of nutrients into cells, the removal of metabolic wastes and xenobiotics (including drugs), and the generation and maintenance of transmembrane electrochemical gradients. In this chapter we review the present state of knowledge of the membrane transport mechanisms...[Show more]

dc.contributor.authorKirk, Kiaran
dc.contributor.authorMartin, Rowena
dc.contributor.authorBroer, Stefan
dc.contributor.authorHowitt, Susan
dc.contributor.authorSaliba, Kevin
dc.date.accessioned2015-12-13T23:01:29Z
dc.date.available2015-12-13T23:01:29Z
dc.identifier.issn0070-217X
dc.identifier.urihttp://hdl.handle.net/1885/84458
dc.description.abstractMembrane transport proteins are integral membrane proteins that mediate the passage across the membrane bilayer of specific molecules and/or ions. Such proteins serve a diverse range of physiological roles, mediating the uptake of nutrients into cells, the removal of metabolic wastes and xenobiotics (including drugs), and the generation and maintenance of transmembrane electrochemical gradients. In this chapter we review the present state of knowledge of the membrane transport mechanisms underlying the cell physiology of the intraerythrocytic malaria parasite and its host cell, considering in particular physiological measurements on the parasite and parasitized erythrocyte, the annotation of transport proteins in the Plasmodium genome, and molecular methods used to analyze transport protein function.
dc.publisherSpringer
dc.sourceCurrent Topics in Microbiology and Immunology
dc.subjectKeywords: carrier protein; xenobiotic agent; cell function; cell membrane; cell vacuole; cellular distribution; erythrocyte; gene mutation; genome; host cell; malaria; membrane electrophysiology; nonhuman; nutrient uptake; oocyte; parasite isolation; Plasmodium fal
dc.titlePlasmodium permeomics: membrane transport proteins in the malaria parasite.
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume295
dc.date.issued2005
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absfor060502 - Infectious Agents
local.identifier.ariespublicationMigratedxPub12727
local.type.statusPublished Version
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMartin, Rowena, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBroer, Stefan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHowitt, Susan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSaliba, Kevin, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.startpage325
local.bibliographicCitation.lastpage56
dc.date.updated2015-12-12T07:40:43Z
local.identifier.scopusID2-s2.0-24144442901
CollectionsANU Research Publications

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