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Follicular B helper T cells in antibody responses and autoimmunity

Garcia De Vinuesa, Maria Carola; Tangye, Stuart G; Moser, Bernhard; Mackay, Charles R

Description

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4+ T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper...[Show more]

dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.contributor.authorTangye, Stuart G
dc.contributor.authorMoser, Bernhard
dc.contributor.authorMackay, Charles R
dc.date.accessioned2015-12-13T23:00:55Z
dc.identifier.issn1474-1733
dc.identifier.urihttp://hdl.handle.net/1885/84352
dc.description.abstractT-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4+ T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.
dc.publisherNature Publishing Group
dc.sourceNature Reviews Immunology
dc.subjectKeywords: CD40 ligand; chemokine receptor CCR5; interleukin 10; transcription factor; antibody response; autoimmunity; B lymphocyte; cell differentiation; cell growth; cell maturation; cell migration; cell survival; cellular immunity; gene expression; gene mutation
dc.titleFollicular B helper T cells in antibody responses and autoimmunity
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume5
dc.date.issued2005
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationMigratedxPub12632
local.type.statusPublished Version
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTangye, Stuart G, Centenary Institute of Cancer Medicine and Cell Biology
local.contributor.affiliationMoser, Bernhard, University of Bern
local.contributor.affiliationMackay, Charles R, Garvan Institute of Medical Research
local.description.embargo2037-12-31
local.bibliographicCitation.startpage853
local.bibliographicCitation.lastpage865
local.identifier.doi10.1038/nri1714
dc.date.updated2015-12-12T07:36:46Z
local.identifier.scopusID2-s2.0-27744498868
CollectionsANU Research Publications

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