Garcia De Vinuesa, Maria Carola; Tangye, Stuart G; Moser, Bernhard; Mackay, Charles R
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4+ T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper...[Show more]
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