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Deficiency of glutathione transferase Zeta causes oxidative stress and activation of antioxidant response pathways

Blackburn, Anneke; Matthaei, Klaus; Lim, Cindy; Taylor, Matthew; Cappello, Jean; Hayes, John D.; Anders, Michael; Board, Philip


Glutathione S-transferase (GST) zeta (GSTZ1-1) plays a significant role in the catabolism of phenylalanine and tyrosine, and a deficiency of GSTZ1-1 results in the accumulation of maleylacetoacetate and its derivatives maleylacetone (MA) and succinylacetone. Induction of GST subunits was detected in the liver of Gstz1-/- mice by Western blotting with specific antisera and high-performance liquid chromatography analysis of glutathione affinity column-purified proteins. The greatest induction was...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Molecular Pharmacology
DOI: 10.1124/mol.105.018911


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