A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes
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Wang, Jun; Shannon, M Frances; Young, Ian
Description
IL-5 is a key regulator of eosinophilic inflammation and is selectively expressed by antigen-activated Th2 lymphocytes. An important role for the proximal AP-1 and GATA sites in regulating IL-5 transcription is generally accepted but the significance of an adjacent Ets/NFAT site has remained unclear. We have investigated its role using the mouse Th2 clone D10.G4.1. Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/ cyclic adenosine...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/84337 |
Source: | International Immunology |
DOI: | 10.1093/intimm/dxh370 |
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01_Wang_A_role_for_Ets1,_synergizing_2006.pdf | 299.22 kB | Adobe PDF | Request a copy |
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