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A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes

Wang, Jun; Shannon, M Frances; Young, Ian


IL-5 is a key regulator of eosinophilic inflammation and is selectively expressed by antigen-activated Th2 lymphocytes. An important role for the proximal AP-1 and GATA sites in regulating IL-5 transcription is generally accepted but the significance of an adjacent Ets/NFAT site has remained unclear. We have investigated its role using the mouse Th2 clone D10.G4.1. Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/ cyclic adenosine...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: International Immunology
DOI: 10.1093/intimm/dxh370


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