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The Australiasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-Acetylcysteine

Kerr, Fergus; Dawson, Andrew; Whyte, Ian M; Buckley, Nicholas; Murray, Lindsay; Graudins, Andis; Chan, Betty; Trudinger, Barbara


Study objective: We determine whether the incidence of adverse events caused by intravenous N-acetylcysteine is significantly less when the initial dose is infused over a 60-minute period compared with the standard infusion period of 15 minutes. A secondary objective is to assess the efficacy of the 2 treatment arms. Methods: This was a multicenter, randomized, prospective trial of patients who presented with acetaminophen poisoning and who were treated with N-acetylcysteine and had no history...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Annals of Emergency Medicine
DOI: 10.1016/j.annemergmed.2004.08.040


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