Preferred stereoselective transport of the D-isomer of cis-4-(18F)fluoro-proline at the blood-brain barrier
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Langen, Karl-Josef; Hamacher, Kurt; Bauer, Dagmar; Broer, Stefan; Pauleit, Dirk; Herzog, Hans; Floeth, Frank; Zilles, Karl; Coenen, Heinz
Description
Generally, L-amino acids are preferably transported into mammalian cells compared with their D-isomers, and only L-amino acids are incorporated into proteins. Former studies, however, indicated that D-[H]proline is accumulated in the brain of mice after injection, while L-[3H]proline is not. We investigated the differential cerebral uptake of the D- and L-isomers of the PET tracer cis-4-[18F]fluoroproline (D-/L-cis-FPro) and of D-/L-[ 3H]proline (D-/L-Pro) in rats by dual tracer autoradiography...[Show more]
Collections | ANU Research Publications |
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Date published: | 2005 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/84148 |
Source: | Journal of Cerebral Blood Flow and Metabolism |
DOI: | 10.1038/sj.jcbfm.9600065 |
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