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Preferred stereoselective transport of the D-isomer of cis-4-(18F)fluoro-proline at the blood-brain barrier

Langen, Karl-Josef; Hamacher, Kurt; Bauer, Dagmar; Broer, Stefan; Pauleit, Dirk; Herzog, Hans; Floeth, Frank; Zilles, Karl; Coenen, Heinz


Generally, L-amino acids are preferably transported into mammalian cells compared with their D-isomers, and only L-amino acids are incorporated into proteins. Former studies, however, indicated that D-[H]proline is accumulated in the brain of mice after injection, while L-[3H]proline is not. We investigated the differential cerebral uptake of the D- and L-isomers of the PET tracer cis-4-[18F]fluoroproline (D-/L-cis-FPro) and of D-/L-[ 3H]proline (D-/L-Pro) in rats by dual tracer autoradiography...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Cerebral Blood Flow and Metabolism
DOI: 10.1038/sj.jcbfm.9600065


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