Langen, Karl-Josef; Hamacher, Kurt; Bauer, Dagmar; Broer, Stefan; Pauleit, Dirk; Herzog, Hans; Floeth, Frank; Zilles, Karl; Coenen, Heinz
Generally, L-amino acids are preferably transported into mammalian cells compared with their D-isomers, and only L-amino acids are incorporated into proteins. Former studies, however, indicated that D-[H]proline is accumulated in the brain of mice after injection, while L-[3H]proline is not. We investigated the differential cerebral uptake of the D- and L-isomers of the PET tracer cis-4-[18F]fluoroproline (D-/L-cis-FPro) and of D-/L-[ 3H]proline (D-/L-Pro) in rats by dual tracer autoradiography...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.