Bauer, Dagmar; Hamacher, Kurt; Broer, Stefan; Pauleit, Dirk; Palm, Christoph; Zilles, Karl; Coenen, Heinz; Langen, Karl-Josef
Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.