Preferred stereoselective brain uptake of D-serine-a modulator of glutamatergic neurotransmission
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Bauer, Dagmar; Hamacher, Kurt; Broer, Stefan; Pauleit, Dirk; Palm, Christoph; Zilles, Karl; Coenen, Heinz; Langen, Karl-Josef
Description
Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of...[Show more]
Collections | ANU Research Publications |
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Date published: | 2005 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/84147 |
Source: | Nuclear Medicine and Biology |
DOI: | 10.1016/j.nucmedbio.2005.07.004 |
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