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Preferred stereoselective brain uptake of D-serine-a modulator of glutamatergic neurotransmission

Bauer, Dagmar; Hamacher, Kurt; Broer, Stefan; Pauleit, Dirk; Palm, Christoph; Zilles, Karl; Coenen, Heinz; Langen, Karl-Josef


Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Nuclear Medicine and Biology
DOI: 10.1016/j.nucmedbio.2005.07.004


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