Rosen, David B; Bettadapura, Jayaram; Alsharifi, Mohammed; Mathew, Porunelloor A; Warren, Hilary; Lanier, Lewis L
Increasingly, roles are emerging for C-type lectin receptors in immune regulation. One receptor whose function has remained largely enigmatic is human NKR-P1A (CD161), present on NK cells and subsets of T cells. In this study, we demonstrate that the lectin-like transcript-1 (LLT1) is a physiologic ligand for NKR-P1A. LLT1-containing liposomes bind to NKR-P1A+ cells, and binding is inhibited by anti-NKR-P1A mAb. Additionally, LLT1 activates NFA T-GFP reporter cells expressing CD3ζ NKR-P1A...[Show more]
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