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Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators

Archer, Stuart; Claudianos, Charles; Campbell, Hugh


The gelsolin gene family encodes a number of higher eukaryotic actin-binding proteins that are thought to function in the cytoplasm by severing, capping, nucleating or bundling actin filaments. Recent evidence, however, suggests that several members of the gelsolin family may have adopted unexpected nuclear functions including a role in regulating transcription. In particular, flightless I, supervillin and gelsolin itself have roles as coactivators for nuclear receptors, despite the fact that...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Bioessays
DOI: 10.1002/bies.20200


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