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Connecting Mammalian Genome with Phenome by ENU Mouse Mutagenesis: Gene Combinations Specifying the Immune System

Papathanasiou, Panagiotis; Goodnow, Christopher


The human and mouse genome sequences bring closer the goal of understanding how characteristics of adult mammalian physiology and pathology are encoded by DNA. Here we review the challenge of understanding how genes specify mammalian traits, with particular focus on the cells and behavior of the immune system. Summarized is the emerging experience, advantages, and limitations of using ethylnitrosourea (ENU) to modify the mouse genome and select informative variants by phenotypic screens,...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Annual Review of Genetics
DOI: 10.1146/annurev.genet.39.110304.095817


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