Thomson, Scott; Jaramillo, Angel B; Shoobridge, Maryanne; Dunstan, Kerrie J; Everett, Beth; Ranasinghe, Charani; Kent, Stephen J; Gao, Ke; Medveczky, C; Ffrench, Rosemary A; Ramshaw, Ian
Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode more antigens safely and is very flexible compared to traditional isolate-based strategies. The SAVINE...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.