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Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use

Thomson, Scott; Jaramillo, Angel B; Shoobridge, Maryanne; Dunstan, Kerrie J; Everett, Beth; Ranasinghe, Charani; Kent, Stephen J; Gao, Ke; Medveczky, C; Ffrench, Rosemary A; Ramshaw, Ian

Description

Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode more antigens safely and is very flexible compared to traditional isolate-based strategies. The SAVINE...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/84024
Source: Vaccine
DOI: 10.1016/j.vaccine.2005.04.045

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