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Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3

Kent, Stephen J; Dale, C Jane; Stratov, Ivan; De Rose, Robert; Chea, Socheata; Montefiori, David C; Thomson, Scott; Ramshaw, Ian; Coupar, Barbara E H; Boyle, David B; Law, Matthew G; Wilson, Kim M; Ramsay, Alistair; Ranasinghe, Charani

Description

Further advances are required in understanding protection from AIDS by T cell immunity across mucosal sites of virus transmission. We analysed a set of multigenic HIV and SHIV DNA and Fowlpoxvirus (FPV) prime and boost vaccines for immunogenicity and protective efficacy in outbred pigtail macaques when delivered via mucosal surfaces (intranasally or intrarectally). Intranasally delivered DNA, even when adjuvanted and given as a fine droplet spray, was neither immunogenic nor protective in...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/84023
Source: Vaccine
DOI: 10.1016/j.vaccine.2005.05.032

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