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Modulation of voltage-dependant Ba2+ currents in the guinea-pig gastric antrum by cyclic nucleotide-dependent pathways

Zhu, Hai-Lei; Hirst, George; Ito, Yushi; Teramoto, Noriyoshi


We have investigated whether the activation of cAMP- and cGMP-dependent pathways modifies the properties of voltage-dependent Ba 2+ currents (I Ba) recorded from guinea-pig gastric myocytes using patch-clamp techniques. All experiments were carried on single smooth muscle cells, dispersed from the circular layer of the guinea-pig gastric antrum. Both dibutyryl cAMP (db-cAMP, 0.1-1 mM), a membrane-permeable ester of cAMP, and isoproterenol, a selective β-stimulant, inhibited I Ba in a...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: British Journal of Pharmacology
DOI: 10.1038/sj.bjp.0706295


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