Modulation of voltage-dependant Ba2+ currents in the guinea-pig gastric antrum by cyclic nucleotide-dependent pathways
We have investigated whether the activation of cAMP- and cGMP-dependent pathways modifies the properties of voltage-dependent Ba 2+ currents (I Ba) recorded from guinea-pig gastric myocytes using patch-clamp techniques. All experiments were carried on single smooth muscle cells, dispersed from the circular layer of the guinea-pig gastric antrum. Both dibutyryl cAMP (db-cAMP, 0.1-1 mM), a membrane-permeable ester of cAMP, and isoproterenol, a selective β-stimulant, inhibited I Ba in a...[Show more]
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|Source:||British Journal of Pharmacology|
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