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Cefoxitin resistance as a surrogte marker for the detection of methiciliin-resistanct staphylococcus aureus

Fernandes, Clarence J; Fernandes, Lorna A; Collignon, Peter

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Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for...[Show more]

dc.contributor.authorFernandes, Clarence J
dc.contributor.authorFernandes, Lorna A
dc.contributor.authorCollignon, Peter
dc.date.accessioned2015-12-13T22:59:17Z
dc.date.available2015-12-13T22:59:17Z
dc.identifier.issn0305-7453
dc.identifier.urihttp://hdl.handle.net/1885/83697
dc.description.abstractObjectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.
dc.publisherOxford University Press
dc.sourceJournal of Antimicrobial Chemotherapy
dc.subjectKeywords: cefoxitin; meticillin; oxacillin; agar gel diffusion; antibiotic resistance; antibiotic sensitivity; article; bacterial strain; bacterium detection; controlled study; diagnostic accuracy; dilution; human; methicillin resistant Staphylococcus aureus; nonhu Community-onset MRSA infections; Hospital-acquired infections; Non-multiresistant staphylococcus aureus; Oxacillin resistance
dc.titleCefoxitin resistance as a surrogte marker for the detection of methiciliin-resistanct staphylococcus aureus
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume55
dc.date.issued2005
local.identifier.absfor110309 - Infectious Diseases
local.identifier.ariespublicationMigratedxPub11981
local.type.statusPublished Version
local.contributor.affiliationFernandes, Clarence J, Royal North Shore Hospital
local.contributor.affiliationFernandes, Lorna A, Royal North Shore Hospital
local.contributor.affiliationCollignon, Peter, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage506
local.bibliographicCitation.lastpage10
local.identifier.doi10.1093/jac/dki052
dc.date.updated2015-12-12T07:27:24Z
local.identifier.scopusID2-s2.0-20244388509
CollectionsANU Research Publications

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