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A repository of ENU mutant mouse lines and their potential for male fertility research

Kennedy, Claire L; O'Connor, Alan; Sanchez-Partida, Luis; Holland, Michael; Goodnow, Christopher; de Kretser, David M; O'Bryan, Moira K


Many of the proteins and their encoding genes involved in spermatogenesis are unknown, making the specific diagnosis and treatment of infertility in males difficult and highlighting the importance of identifying new genes that are involved in spermatogenesis. Through genome-wide chemical mutagenesis using N-ethyl-nitrosourea (ENU) and a three-generation breeding scheme to isolate recessive mutations, we have identified mouse lines with a range of abnormalities relevant to human male fertility....[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Molecular Human Reproduction
DOI: 10.1093/molehr/gah251


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