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A prospective study of treatment with selective internal radiation therapy spheres in patients with unresectable primary or secondary hepatic malignancies

Lim, Lionel; Gibbs, Peter; Yip, Desmond; Shapiro, Jeremy; Dowling, Robyn; Smith, D; Little, A; Bailey, W; Liechtenstein, Meir

Description

Aim: To prospectively evaluate the efficacy and safety of Selective Internal Radiation (SIR) Spheres (Sirtex Medical, Sydney, NSW, Australia) in patients with unresectable primary or secondary hepatic malignancies. Methods: We report our experience of SIR sphere therapy at three Australian centres. Patients with previously untreated colorectal cancer (CRC) received concurrent 5FU, other patients with CRC received 5-FU at investigator discretion and all other patients received SIR spheres alone....[Show more]

dc.contributor.authorLim, Lionel
dc.contributor.authorGibbs, Peter
dc.contributor.authorYip, Desmond
dc.contributor.authorShapiro, Jeremy
dc.contributor.authorDowling, Robyn
dc.contributor.authorSmith, D
dc.contributor.authorLittle, A
dc.contributor.authorBailey, W
dc.contributor.authorLiechtenstein, Meir
dc.date.accessioned2015-12-13T22:59:03Z
dc.identifier.issn1444-0903
dc.identifier.urihttp://hdl.handle.net/1885/83585
dc.description.abstractAim: To prospectively evaluate the efficacy and safety of Selective Internal Radiation (SIR) Spheres (Sirtex Medical, Sydney, NSW, Australia) in patients with unresectable primary or secondary hepatic malignancies. Methods: We report our experience of SIR sphere therapy at three Australian centres. Patients with previously untreated colorectal cancer (CRC) received concurrent 5FU, other patients with CRC received 5-FU at investigator discretion and all other patients received SIR spheres alone. Results: Forty-six patients were enrolled between January 2002 and June 2003. The majority (32 patients) had metastatic colorectal cancer and five patients had hepatocellular carcinoma. The median age of patients was 64 years (range 46-78 years). Forty-three patients were evaluable for response. There were 12 partial responses, of which 10 were in patients with CRC. The median duration of response for all patients was 8.6 months (range 2-21 months). Overall treatment related toxicity was acceptable. Significant late toxicity included four cases of severe gastric ulceration, despite standard work-up and treatment by experienced interventional radiologists. Conclusion: In this series of patients, treatment with SIR-spheres has demonstrated modest activity, mostly observed in patients with CRC. Toxicity was substantial in a small number of patients.
dc.publisherBlackwell Science Asia
dc.sourceInternal Medicine Journal
dc.subjectKeywords: fluorouracil; adult; aged; article; Australia; cancer radiotherapy; cancer surgery; clinical article; colorectal cancer; female; human; interventional radiology; liver cell carcinoma; male; metastasis; priority journal; prospective study; stomach ulcer; A Colorectal cancer; Hepatic malignancies; Hepatocellular carcinoma; Liver metastases; SIR-spheres
dc.titleA prospective study of treatment with selective internal radiation therapy spheres in patients with unresectable primary or secondary hepatic malignancies
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume35
dc.date.issued2005
local.identifier.absfor111299 - Oncology and Carcinogenesis not elsewhere classified
local.identifier.ariespublicationMigratedxPub11874
local.type.statusPublished Version
local.contributor.affiliationLim, Lionel, Royal Melbourne Hospital
local.contributor.affiliationGibbs, Peter, Royal Melbourne Hospital
local.contributor.affiliationYip, Desmond, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationShapiro, Jeremy, Cabrini Hospital Malvern
local.contributor.affiliationDowling, Robyn, Macquarie University
local.contributor.affiliationSmith, D, The Canberra Hospital
local.contributor.affiliationLittle, A, Cabrini Hospital Malvern
local.contributor.affiliationBailey, W, Cabrini Hospital Malvern
local.contributor.affiliationLiechtenstein, Meir, Royal Melbourne Hospital
local.description.embargo2037-12-31
local.bibliographicCitation.startpage222
local.bibliographicCitation.lastpage227
local.identifier.doi10.1111/j.1445-5994.2005.00789.x
dc.date.updated2015-12-12T07:26:11Z
local.identifier.scopusID2-s2.0-17244363776
CollectionsANU Research Publications

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