Clarke, Stephen J; Boyer, Michael J; Millward, Michael; Underhill, Craig; Moylan, Eugene; Yip, Desmond; White, Shane; Childs, Annabel; Beale, Phillip; Latz, Jane; Suri, Ajit; Iglesias, Jose
Purpose: Pemetrexed and vinorelbine are active antineoplastic agents in non-small cell lung cancer (NSCLC). Phase I objectives include maximum tolerated dose (MTD) and recommended phase II dose determination, and pharmacokinetics of the pemetrexed-vinorelbine doublet in locally advanced or metastatic solid tumor patients (pts). Phase II objectives include tumor response evaluation, efficacy, and toxicity for first-line treatment of advanced NSCLC. Experimental design: Phase I pts received...[Show more]
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