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Associations between plasma antioxidants and hypertension in a community based sample aged 60- 64 years

Parslow, Ruth; Sachdev, Perminder Singh; Salonikas, Chris; Lux, Ora; Jorm, Anthony F; Naidoo, Daya

Description

It has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. In vivo oxidation of low-density lipoproteins by oxygen-free radicals may increase hypertension-related atherogenesis, and antioxidants may be beneficial in this regard. Previous findings concerning associations between serum measures of antioxidants; and hypertension have however been inconsistent. Plasma levels of β-carotene, Vitamin A, E, uric acid, homocysteine and total...[Show more]

dc.contributor.authorParslow, Ruth
dc.contributor.authorSachdev, Perminder Singh
dc.contributor.authorSalonikas, Chris
dc.contributor.authorLux, Ora
dc.contributor.authorJorm, Anthony F
dc.contributor.authorNaidoo, Daya
dc.date.accessioned2015-12-13T22:58:48Z
dc.identifier.issn0950-9240
dc.identifier.urihttp://hdl.handle.net/1885/83466
dc.description.abstractIt has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. In vivo oxidation of low-density lipoproteins by oxygen-free radicals may increase hypertension-related atherogenesis, and antioxidants may be beneficial in this regard. Previous findings concerning associations between serum measures of antioxidants; and hypertension have however been inconsistent. Plasma levels of β-carotene, Vitamin A, E, uric acid, homocysteine and total antioxidant capacity, as well as two markers of oxidative stress, malondialdehyde (MDA) and protein carbonyls, were measured in morning fasting blood samples provided by 415 Australians aged 60-64 years, selected randomly from the community. Participants also provided information on sociodemographic attributes, mental and physical health, and provided two measures of resting blood pressure, allowing a diagnosis of definite or borderline hypertension. Those with hypertension had lower levels of β-carotene and higher levels of uric acid and MDA compared to normotensive participants. The last two of these associations persisted when the analyses controlled for lifestyle and health factors. The findings from this study offer limited support for the proposition that lower antioxidant status and higher oxidative stress are associated with hypertension, and suggest the need for longitudinal studies to examine causality and intervention studies to determine the benefit of antioxidants in this group.
dc.publisherNature Publishing Group
dc.sourceJournal of Human Hypertension
dc.subjectKeywords: alpha tocopherol; antioxidant; beta carotene; carbonyl derivative; homocysteine; low density lipoprotein; malonaldehyde; oxygen radical; retinol; uric acid; adult; article; atherogenesis; Australia; blood pressure measurement; blood sampling; community; c Antioxidants; Epidemiology; Older adults
dc.titleAssociations between plasma antioxidants and hypertension in a community based sample aged 60- 64 years
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume19
dc.date.issued2005
local.identifier.absfor111714 - Mental Health
local.identifier.ariespublicationMigratedxPub11748
local.type.statusPublished Version
local.contributor.affiliationParslow, Ruth, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSachdev, Perminder Singh, University of New South Wales (Prince of Wales Hospital)
local.contributor.affiliationSalonikas, Chris, Prince of Wales Hospital
local.contributor.affiliationLux, Ora, Prince of Wales Hospital
local.contributor.affiliationJorm, Anthony F, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationNaidoo, Daya, Prince of Wales Hospital
local.description.embargo2037-12-31
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage173
local.bibliographicCitation.lastpage183
local.identifier.doi10.1038/sj.jhh.1001809
dc.date.updated2015-12-12T07:24:48Z
local.identifier.scopusID2-s2.0-14944369168
CollectionsANU Research Publications

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