The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background
Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element...[Show more]
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|Source:||FEMS Immunology and Medical Microbiology|
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