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The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

Roberts, Fleur; Jennison, Amy; Verma, Naresh

Description

Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/83453
Source: FEMS Immunology and Medical Microbiology
DOI: 10.1016/j.femsim.2005.05.002

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