Provitamin B5 (Pantothenol) Inhibits Growth of the Intraerythrocytic Malaria Parasite
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Saliba, Kevin; Ferru, Isabelle; Kirk, Kiaran
Description
Pantothenic acid, a precursor of the crucial enzyme cofactor coenzyme A, is one of a relatively few nutrients for which the intraerythrocytic parasite has an absolute and acute requirement from the external medium. In some organisms the provitamin pantothenol can serve as a source of pantothenic acid; however, this was not the case for the human malaria parasite Plasmodium falciparum. Instead, pantothenol inhibited the in vitro growth of P. falciparum via a mechanism that involves competition...[Show more]
Collections | ANU Research Publications |
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Date published: | 2005 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/83452 |
Source: | Antimicrobial Agents and Chemotherapy |
DOI: | 10.1128/AAC.49.2.632-637.2005 |
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01_Saliba_Provitamin_B5_(Pantothenol)_2005.pdf | 218.29 kB | Adobe PDF | Request a copy |
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