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Provitamin B5 (Pantothenol) Inhibits Growth of the Intraerythrocytic Malaria Parasite

Saliba, Kevin; Ferru, Isabelle; Kirk, Kiaran

Description

Pantothenic acid, a precursor of the crucial enzyme cofactor coenzyme A, is one of a relatively few nutrients for which the intraerythrocytic parasite has an absolute and acute requirement from the external medium. In some organisms the provitamin pantothenol can serve as a source of pantothenic acid; however, this was not the case for the human malaria parasite Plasmodium falciparum. Instead, pantothenol inhibited the in vitro growth of P. falciparum via a mechanism that involves competition...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/83452
Source: Antimicrobial Agents and Chemotherapy
DOI: 10.1128/AAC.49.2.632-637.2005

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