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A Class of Pantothenic Acid Analogs Inhibits Plasmodium falciparum Pantothenate Kinase and Represses the Proliferation of Malaria Parasites

Spry, Christina; Chai, Christina; Kirk, Kiaran; Saliba, Kevin


The growth and proliferation of the human malaria parasite Plasmodium falciparum are dependent on the parasite's ability to obtain essential nutrients. One nutrient for which the parasite has an absolute requirement is the water-soluble vitamin pantothenic acid (vitamin B5). In this study, a series of pantothenic acid analogs which retain the 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenic acid but deviate in structure from one another and from pantothenic acid in the nature of the...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Antimicrobial Agents and Chemotherapy
DOI: 10.1128/AAC.49.11.4649-4657.2005


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